Centella asiatica, commonly known as Gotu Kola, has therapeutic properties, particularly in enhancing cognitive function and alleviating anxiety. A newly standardized extract with Centella asiatica bioavailability in dogs in mind has been developed. The herb extract has has improved water solubility. This advancement is significant as it enhances the bioavailability of its active compounds, particularly triterpenoids, which have beneficial effects in both humans and animals.
Pharmacokinetic Study in Beagle Dogs
A study investigated the pharmacokinetic profiles of bioactive triterpenoids from Centell-S in beagle dogs. The study involved administering the extract through both intravenous and oral routes over a period of seven days. Key bioactive components such as madecassoside, asiaticoside, madecassic acid, and asiatic acid were measured using liquid chromatography–tandem mass spectrometry. The results indicated that these compounds achieved significant concentrations in the systemic circulation, highlighting the effective absorption and distribution of Centell-S in canine subjects.
Tolerability and Safety Profile
The beagle dogs demonstrated excellent tolerability to both Centell-S and ECa 233. Physical examinations and blood chemistry analyses conducted 24 hours post-dosing showed no adverse effects. This safety profile is crucial for veterinarians considering herbal treatments for anxiety and cognitive dysfunction in dogs It ensures use without significant risk to animal health.
Enhanced Bioavailability of Active Compounds
One of the most notable findings from this research was that Centell-S significantly increased the oral bioavailability of triterpenoid glycosides compared to ECa 233. Specifically, oral doses of 10 and 20 mg/kg Centell-S resulted in approximately double the plasma levels of madecassoside and asiaticoside compared to equivalent doses of ECa 233. This enhanced bioavailability suggests that Centell-S could be more effective in delivering therapeutic benefits to dogs suffering from anxiety or cognitive issues.
Implications for Phytopharmaceutical Development
The promising pharmacokinetic results from this study open avenues for developing Centell-S into a phytopharmaceutical product. The increased efficacy and safety profile of Centell-S could lead to new treatment options for canine anxiety and cognitive dysfunction.
Conclusion
In conclusion, Centella asiatica’s newly standardized extract shows great promise in veterinary applications due to its enhanced solubility and bioavailability. The favorable pharmacokinetic profiles observed in beagle dogs suggest that this extract could serve as a viable option for addressing anxiety and cognitive function issues in dogs. As research continues, veterinarians may soon have access to effective phytopharmaceutical treatments derived from Centella asiatica and other herbs.
